Spyre Therapeutics Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| BLACKROCK, INC. | 02/12/2026 | 5.52 M | $180.90 M | 38.65% | 7.37% |
| RTW INVESTMENTS, LP | 02/17/2026 | 4.17 M | $136.67 M | 15.19% | 5.57% |
| VANGUARD GROUP INC | 01/29/2026 | 4.04 M | $132.19 M | 32.27% | 5.39% |
| FAIRMOUNT FUNDS MANAGEMENT LLC | 02/17/2026 | 4.02 M | $131.63 M | 0.00% | 5.36% |
| CAPITAL INTERNATIONAL INVESTORS | 02/11/2026 | 3.49 M | $114.42 M | 45.98% | 4.66% |
| PERCEPTIVE ADVISORS LLC | 02/17/2026 | 3.07 M | $100.55 M | 149.64% | 4.10% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 02/17/2026 | 2.88 M | $94.43 M | 39.90% | 3.85% |
| COMMODORE CAPITAL LP | 02/17/2026 | 2.39 M | $78.24 M | 20.13% | 3.19% |
| STATE STREET CORP | 02/13/2026 | 2.26 M | $74.13 M | 26.76% | 3.02% |
| TCG CROSSOVER MANAGEMENT, LLC | 02/17/2026 | 1.90 M | $62.26 M | 72.69% | 2.54% |
| TANG CAPITAL MANAGEMENT LLC | 02/17/2026 | 1.89 M | $61.99 M | -40.87% | 2.53% |
| JANUS HENDERSON GROUP PLC | 02/17/2026 | 1.83 M | $59.92 M | 13,969.30% | 2.44% |
| GEODE CAPITAL MANAGEMENT, LLC | 02/09/2026 | 1.66 M | $54.36 M | 35.42% | 2.21% |
| BRAIDWELL LP | 02/17/2026 | 1.63 M | $53.55 M | -36.60% | 2.18% |
| RA CAPITAL MANAGEMENT, L.P. | 02/17/2026 | 1.62 M | $53.12 M | 100.00% | 2.16% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 02/17/2026 | 1.60 M | $52.48 M | 158.11% | 2.14% |
| WELLINGTON MANAGEMENT GROUP LLP | 02/17/2026 | 1.55 M | $50.75 M | -5.55% | 2.07% |
| PARADIGM BIOCAPITAL ADVISORS LP | 02/17/2026 | 1.47 M | $48.07 M | 0.00% | 1.96% |
| 02/12/2026 | 1.46 M | $47.71 M | 100.00% | 1.94% | |
| AFFINITY ASSET ADVISORS, LLC | 02/13/2026 | 1.43 M | $46.93 M | 0.94% | 1.91% |
| FRANKLIN RESOURCES INC | 02/11/2026 | 1.11 M | $36.34 M | 39.48% | 1.48% |
| BAKER BROS. ADVISORS LP | 02/17/2026 | 1.00 M | $32.76 M | 0.00% | 1.33% |
| PICTET ASSET MANAGEMENT HOLDING SA | 01/29/2026 | 913.96 K | $29.94 M | -11.80% | 1.22% |
| SIREN, L.L.C. | 02/13/2026 | 818.60 K | $26.82 M | 122.08% | 1.09% |
| POLAR CAPITAL HOLDINGS PLC | 02/17/2026 | 740.33 K | $24.25 M | -6.14% | 0.99% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 02/17/2026 | 710.63 K | $23.28 M | 15.80% | 0.95% |
| UBS GROUP AG | 01/29/2026 | 680.57 K | $22.30 M | 76.50% | 0.91% |
| EMERALD ADVISERS, LLC | 02/09/2026 | 636.11 K | $20.84 M | 15.93% | 0.85% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 02/13/2026 | 574.62 K | $18.82 M | 35.10% | 0.77% |
| NORTHERN TRUST CORP | 02/17/2026 | 561.02 K | $18.38 M | 26.92% | 0.75% |
| BLACKSTONE INC. | 02/17/2026 | 501.00 K | $16.41 M | 0.00% | 0.67% |
| CANDRIAM S.C.A. | 02/13/2026 | 425.53 K | $13.94 M | 5.24% | 0.57% |
| BANK OF AMERICA CORP /DE/ | 02/17/2026 | 419.73 K | $13.75 M | 21.73% | 0.56% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 02/09/2026 | 412.37 K | $13.51 M | 33.79% | 0.55% |
| CAPTION MANAGEMENT, LLC | 02/17/2026 | 399.90 K | $13.10 M | 369.37% | 0.53% |
| GOLDMAN SACHS GROUP INC | 02/10/2026 | 275.07 K | $9.01 M | -16.53% | 0.37% |
| WOODLINE PARTNERS LP | 02/17/2026 | 265.89 K | $8.71 M | 101.62% | 0.35% |
| CAPITAL WORLD INVESTORS | 02/11/2026 | 200.17 K | $6.56 M | 0.00% | 0.27% |
| ARMISTICE CAPITAL, LLC | 02/17/2026 | 196.43 K | $6.43 M | 25.91% | 0.26% |
| BANK OF NEW YORK MELLON CORP | 02/10/2026 | 192.83 K | $6.32 M | 41.83% | 0.26% |
| HIGHVISTA STRATEGIES LLC | 02/17/2026 | 188.21 K | $6.17 M | -12.77% | 0.25% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 02/12/2026 | 187.74 K | $6.15 M | 100.00% | 0.25% |
| MORGAN STANLEY | 02/13/2026 | 182.73 K | $5.99 M | -45.41% | 0.24% |
| BARCLAYS PLC | 02/13/2026 | 182.52 K | $5.98 M | 8.43% | 0.24% |
| UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH | 01/28/2026 | 171.21 K | $5.61 M | 55.00% | 0.23% |
| NUVEEN, LLC | 02/12/2026 | 150.98 K | $4.95 M | 56.99% | 0.20% |
| INVESCO LTD. | 02/19/2026 | 150.93 K | $4.94 M | 197.69% | 0.20% |
| PATIENT SQUARE CAPITAL LP | 02/12/2026 | 150.00 K | $4.91 M | 100.00% | 0.20% |
| TD ASSET MANAGEMENT INC | 02/10/2026 | 149.82 K | $4.91 M | 107.03% | 0.20% |
| VICTORY CAPITAL MANAGEMENT INC | 02/13/2026 | 146.08 K | $4.79 M | -55.20% | 0.20% |
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Spyre Therapeutics Inc. institutional Ownership - FAQ's
During the previous two years, 129 institutional investors and hedge funds held shares of Spyre Therapeutics Inc.. The most heavily invested institutionals were:
BlackRock, Inc.: 5.52 M
VANGUARD GROUP INC: 4.04 M
Capital International Investors: 3.49 M
STATE STREET CORP: 2.26 M
GEODE CAPITAL MANAGEMENT, LLC: 1.66 M
Affinity Asset Advisors, LLC: 1.43 M
54.68% of Spyre Therapeutics Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 32.10 M shares in the last 24 months. This purchase volume represents approximately $1.39 B in transactions.