Upstream Bio Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 02/17/2026 | 5.69 M | $154.58 M | 0.00% | 10.56% |
| BLACKROCK, INC. | 02/12/2026 | 3.34 M | $90.80 M | 28.45% | 6.20% |
| DECHENG CAPITAL LLC | 02/12/2026 | 3.14 M | $85.33 M | -4.33% | 5.83% |
| NORGES BANK | 02/10/2026 | 2.88 M | $78.26 M | 100.00% | 5.35% |
| VANGUARD GROUP INC | 01/29/2026 | 2.39 M | $64.85 M | -2.22% | 4.43% |
| UBS GROUP AG | 01/29/2026 | 1.81 M | $49.04 M | 563.40% | 3.35% |
| JANUS HENDERSON GROUP PLC | 02/17/2026 | 1.53 M | $41.42 M | 100.00% | 2.83% |
| ALTSHULER SHAHAM LTD | 02/17/2026 | 1.34 M | $36.42 M | -5.31% | 2.49% |
| OMEGA FUND MANAGEMENT, LLC | 02/17/2026 | 1.33 M | $36.01 M | -2.21% | 2.46% |
| STATE STREET CORP | 02/13/2026 | 1.32 M | $35.82 M | 18.36% | 2.45% |
| WELLINGTON MANAGEMENT GROUP LLP | 02/17/2026 | 894.73 K | $24.29 M | -20.50% | 1.66% |
| GEODE CAPITAL MANAGEMENT, LLC | 02/09/2026 | 851.91 K | $23.13 M | 4.26% | 1.58% |
| PARKMAN HEALTHCARE PARTNERS LLC | 02/17/2026 | 834.56 K | $22.66 M | -1.06% | 1.55% |
| PICTET ASSET MANAGEMENT HOLDING SA | 01/29/2026 | 773.15 K | $20.99 M | 100.00% | 1.43% |
| WOODLINE PARTNERS LP | 02/17/2026 | 760.25 K | $20.64 M | 26.23% | 1.41% |
| INTEGRAL HEALTH ASSET MANAGEMENT, LLC | 02/17/2026 | 750.00 K | $20.36 M | 30.43% | 1.39% |
| TCG CROSSOVER MANAGEMENT, LLC | 02/17/2026 | 743.89 K | $20.20 M | -64.86% | 1.38% |
| SAMSARA BIOCAPITAL, LLC | 02/17/2026 | 736.05 K | $19.98 M | -23.50% | 1.36% |
| VESTAL POINT CAPITAL, LP | 02/17/2026 | 720.00 K | $19.55 M | 100.00% | 1.34% |
| SIREN, L.L.C. | 02/13/2026 | 588.45 K | $15.98 M | -25.37% | 1.09% |
| BARCLAYS PLC | 02/13/2026 | 524.50 K | $14.24 M | 514.78% | 0.97% |
| MILLENNIUM MANAGEMENT LLC | 02/17/2026 | 517.26 K | $14.04 M | 1,189.52% | 0.96% |
| NANTAHALA CAPITAL MANAGEMENT, LLC | 02/13/2026 | 494.97 K | $13.44 M | -16.81% | 0.92% |
| MARSHALL WACE, LLP | 02/13/2026 | 343.79 K | $9.33 M | -60.39% | 0.64% |
| GOLDMAN SACHS GROUP INC | 02/10/2026 | 333.48 K | $9.05 M | 49.40% | 0.62% |
| ALYESKA INVESTMENT GROUP, L.P. | 02/13/2026 | 298.33 K | $8.10 M | 100.00% | 0.55% |
| JENNISON ASSOCIATES LLC | 01/30/2026 | 288.85 K | $7.84 M | 100.00% | 0.54% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 02/13/2026 | 284.93 K | $7.74 M | 0.04% | 0.53% |
| NORTHERN TRUST CORP | 02/17/2026 | 236.80 K | $6.43 M | -7.04% | 0.44% |
| 02/17/2026 | 230.65 K | $6.26 M | 100.00% | 0.43% | |
| INVESCO LTD. | 02/19/2026 | 163.19 K | $4.43 M | 849.31% | 0.30% |
| BOXER CAPITAL MANAGEMENT, LLC | 02/17/2026 | 150.00 K | $4.07 M | 100.00% | 0.28% |
| DEUTSCHE BANK AG\ | 02/11/2026 | 127.82 K | $3.47 M | 378.05% | 0.24% |
| MORGAN STANLEY | 02/13/2026 | 122.07 K | $3.31 M | 39.45% | 0.23% |
| SUMMITTX CAPITAL, L.P. | 02/17/2026 | 116.72 K | $3.17 M | 3.84% | 0.22% |
| JPMORGAN CHASE & CO | 02/11/2026 | 110.28 K | $2.99 M | 268.25% | 0.20% |
| AMERICAN CENTURY COMPANIES INC | 02/13/2026 | 87.76 K | $2.38 M | 22.67% | 0.16% |
| BANK OF AMERICA CORP /DE/ | 02/17/2026 | 86.38 K | $2.35 M | 55.72% | 0.16% |
| BANK OF NEW YORK MELLON CORP | 02/10/2026 | 84.85 K | $2.30 M | -7.29% | 0.16% |
| NUVEEN, LLC | 02/12/2026 | 78.57 K | $2.13 M | 12.43% | 0.15% |
| EXODUSPOINT CAPITAL MANAGEMENT, LP | 02/17/2026 | 75.40 K | $2.05 M | 100.00% | 0.14% |
| ARTIA GLOBAL PARTNERS LP | 02/17/2026 | 68.65 K | $1.86 M | 100.00% | 0.13% |
| EXOME ASSET MANAGEMENT LLC | 02/13/2026 | 64.85 K | $1.76 M | 24.80% | 0.12% |
| AMERIPRISE FINANCIAL INC | 02/17/2026 | 56.56 K | $1.54 M | 100.00% | 0.10% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 02/17/2026 | 55.84 K | $1.52 M | 100.00% | 0.10% |
| SEVEN GRAND MANAGERS, LLC | 02/10/2026 | 50.00 K | $1.36 M | 100.00% | 0.09% |
| Y-INTERCEPT (HONG KONG) LTD | 02/13/2026 | 46.56 K | $1.26 M | 100.00% | 0.09% |
| ALPS ADVISORS INC | 02/12/2026 | 44.38 K | $1.20 M | 70.93% | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 02/17/2026 | 43.50 K | $1.18 M | 100.00% | 0.08% |
| RHUMBLINE ADVISERS | 02/13/2026 | 41.52 K | $1.13 M | -15.96% | 0.08% |
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Upstream Bio Inc. institutional Ownership - FAQ's
During the previous two years, 97 institutional investors and hedge funds held shares of Upstream Bio Inc.. The most heavily invested institutionals were:
BlackRock, Inc.: 3.34 M
Decheng Capital LLC: 3.14 M
NORGES BANK: 2.88 M
VANGUARD GROUP INC: 2.39 M
UBS Group AG: 1.81 M
STATE STREET CORP: 1.32 M
37.78% of Upstream Bio Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 22.57 M shares in the last 24 months. This purchase volume represents approximately $182.35 M in transactions.