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| Reporting Date | Major Shareholder Name | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| 05/15/2024 | TCG CROSSOVER MANAGEMENT, LLC | 3.30 M | $71.18 M | 56.56% | 8.88% |
| 05/17/2024 | ARTAL GROUP S.A. | 2.78 M | $60.04 M | -7.35% | 7.49% |
| 05/15/2024 | LOMBARD ODIER ASSET MANAGEMENT (USA) CORP | 2.39 M | $41.55 M | -38.42% | 6.44% |
| 05/15/2024 | LOMBARD ODIER ASSET MANAGEMENT (EUROPE) LTD | 2.24 M | $48.34 M | -38.05% | 6.03% |
| 05/15/2024 | REDMILE GROUP, LLC | 2.03 M | $43.80 M | 100.00% | 5.47% |
| 05/15/2024 | DEEP TRACK CAPITAL, LP | 1.64 M | $35.51 M | -15.77% | 4.43% |
| 05/15/2024 | LOGOS GLOBAL MANAGEMENT LP | 1.48 M | $31.09 M | 269.02% | 3.98% |
| 05/15/2024 | FRAZIER LIFE SCIENCES MANAGEMENT, L.P. | 1.15 M | $24.81 M | 30.35% | 3.10% |
| 04/22/2024 | VIVO CAPITAL, LLC | 1.11 M | $23.88 M | 116.67% | 2.98% |
| 05/15/2024 | NEXTECH INVEST LTD. | 952,400 | $20.57 M | 100.00% | 2.57% |
| 05/15/2024 | JANUS HENDERSON GROUP PLC | 625,864 | $13.57 M | 100.00% | 1.69% |
| 05/15/2024 | CORMORANT ASSET MANAGEMENT, LP | 625,000 | $13.50 M | 100.00% | 1.69% |
| 05/15/2024 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | $12.96 M | 100.00% | 1.62% |
| 05/15/2024 | AQUILO CAPITAL MANAGEMENT, LLC | 574,214 | $12.40 M | -44.96% | 1.55% |
| 05/15/2024 | LYNX1 CAPITAL MANAGEMENT LP | 526,642 | $11.38 M | 123.36% | 1.42% |
| 05/15/2024 | POLAR CAPITAL HOLDINGS PLC | 500,000 | $10.80 M | 100.00% | 1.35% |
| 05/15/2024 | 5AM VENTURE MANAGEMENT, LLC | 476,200 | $10.29 M | 100.00% | 1.28% |
| 05/15/2024 | MILLENNIUM MANAGEMENT LLC | 409,418 | $8.84 M | 100.00% | 1.10% |
| 05/15/2024 | DUQUESNE FAMILY OFFICE LLC | 387,400 | $8.37 M | 100.00% | 1.04% |
| 05/15/2024 | MANGROVE PARTNERS | 385,408 | $8.32 M | 100.00% | 1.04% |
| 05/15/2024 | OCTAGON CAPITAL ADVISORS LP | 315,000 | $6.80 M | 100.00% | 0.85% |
| 05/14/2024 | M28 CAPITAL MANAGEMENT LP | 299,400 | $6.47 M | -17.70% | 0.81% |
| 05/15/2024 | HUDSON BAY CAPITAL MANAGEMENT LP | 276,590 | $5.97 M | 100.00% | 0.75% |
| 05/15/2024 | PARKMAN HEALTHCARE PARTNERS LLC | 244,471 | $5.28 M | 4.95% | 0.66% |
| 05/15/2024 | MORGAN STANLEY | 242,770 | $5.24 M | 286.53% | 0.65% |
| 05/15/2024 | WOODLINE PARTNERS LP | 238,380 | $5.15 M | 383.80% | 0.64% |
| 05/15/2024 | NANTAHALA CAPITAL MANAGEMENT, LLC | 200,000 | $4.32 M | 100.00% | 0.54% |
| 05/15/2024 | HSBC HOLDINGS PLC | 177,834 | $3.84 M | 0.00% | 0.48% |
| 05/15/2024 | MARSHALL WACE, LLP | 139,191 | $3.01 M | 100.00% | 0.38% |
| 05/15/2024 | SCHONFELD STRATEGIC ADVISORS LLC | 133,000 | $2.87 M | 170.33% | 0.36% |
| 05/15/2024 | BOOTHBAY FUND MANAGEMENT, LLC | 127,224 | $2.75 M | 100.00% | 0.34% |
| 05/15/2024 | TWO SIGMA INVESTMENTS, LP | 107,212 | $2.32 M | 100.00% | 0.29% |
| 05/13/2024 | RENAISSANCE TECHNOLOGIES LLC | 103,900 | $2.24 M | 283.37% | 0.28% |
| 05/15/2024 | CANTOR FITZGERALD, L. P. | 103,483 | $2.24 M | -29.50% | 0.28% |
| 05/15/2024 | WALLEYE CAPITAL LLC | 91,819 | $1.98 M | 100.00% | 0.25% |
| 05/15/2024 | TWO SIGMA ADVISERS, LP | 77,400 | $1.67 M | 100.00% | 0.21% |
| 05/15/2024 | UBS OCONNOR LLC | 72,223 | $1.56 M | -22.51% | 0.19% |
| 05/13/2024 | UBS GROUP AG | 71,918 | $1.55 M | 2.82% | 0.19% |
| 05/10/2024 | CITIGROUP INC | 58,333 | $1.26 M | 0.00% | 0.16% |
| 05/15/2024 | ARTIA GLOBAL PARTNERS LP | 52,476 | $1.13 M | 100.00% | 0.14% |
| 05/15/2024 | CITADEL ADVISORS LLC | 42,682 | $921,931 | 96.36% | 0.12% |
| 05/15/2024 | ADAR1 CAPITAL MANAGEMENT, LLC | 40,090 | $865,944 | 21,000.00% | 0.11% |
| 05/15/2024 | CUBIST SYSTEMATIC STRATEGIES, LLC | 36,281 | $783,670 | 100.00% | 0.10% |
| 05/09/2024 | BLAIR WILLIAM & CO/IL | 25,432 | $549,331 | -0.45% | 0.07% |
| 05/13/2024 | GEODE CAPITAL MANAGEMENT, LLC | 22,427 | $484,423 | 0.00% | 0.06% |
| 05/15/2024 | GOLDMAN SACHS GROUP INC | 21,739 | $469,562 | 100.00% | 0.06% |
| 05/14/2024 | TREXQUANT INVESTMENT LP | 21,047 | $454,615 | 100.00% | 0.06% |
| 05/14/2024 | RATHBONES GROUP PLC | 19,906 | $429,969 | 100.00% | 0.05% |
| 05/13/2024 | JUMP FINANCIAL, LLC | 18,800 | $406,080 | 100.00% | 0.05% |
| 05/15/2024 | SHAY CAPITAL LLC | 15,150 | $327,240 | 100.00% | 0.04% |
A. During the previous two years, 69 institutional investors and hedge funds held shares of Silence Therapeutics plc. The most heavily invested institutionals were:
TCG Crossover Management, LLC: 3.3 M
Artal Group S.A.: 2.78 M
Lombard Odier Asset Management (USA) Corp: 2.39 M
Lombard Odier Asset Management (Europe) Ltd: 2.24 M
Redmile Group, LLC: 2.03 M
Deep Track Capital, LP: 1.64 M
A. 74.50% of Silence Therapeutics plc stock is owned by institutional investors.
A. Institutional investors have bought a total of 27.68 M shares in the last 24 months. This purchase volume represents approximately $497.39 M in transactions.
