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Insider Trading - Adage Capital Management, L.P.

Recent Insider Transactions in Praxis Precision Medicines, Inc. by Adage Capital Management, L.P.

Buy/Sell Shares Bought/Sold @Price Total Transaction Shares Held
After Transaction		 Transaction
Date		 Filling Date Details
Sell 12,600 @ $90.00 $1,134,032 2,361,485 10/16/2025 10/17/2025
Sell 447 @ $91.04 $40,695 2,361,038 10/16/2025 10/17/2025
Sell 1,363 @ $92.03 $125,441 2,359,675 10/16/2025 10/17/2025
Sell 559 @ $100.11 $55,961 2,359,116 10/16/2025 10/17/2025
Sell 27,287 @ $101.00 $2,755,987 2,331,829 10/16/2025 10/17/2025
Sell 250,000 @ $104.31 $26,077,375 2,081,829 10/16/2025 10/17/2025
Sell 1,661 @ $130.10 $216,090 2,080,168 10/16/2025 10/17/2025
Sell 487 @ $131.64 $64,108 2,079,681 10/16/2025 10/17/2025
Sell 308 @ $132.19 $40,715 2,079,373 10/16/2025 10/17/2025
Sell 19,198 @ $140.00 $2,687,720 2,060,175 10/16/2025 10/17/2025

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